FEATURES

FAMILY

DESCRIPTION

Also known as TRPM1_HUMAN, TRPM1, LTRPC1, MLSN, MLSN1. Forms nonselective divalent cation-conducting channels which mediate the influx of Na(2+), Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) into the cytoplasm, leading to membrane depolarization (PubMed:19436059, PubMed:21278253). Impermeable to zinc ions (PubMed:21278253). In addition, forms heteromultimeric ion channels with TRPM3 which are permeable for calcium and zinc ions (PubMed:21278253). Essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. May play a role in metastasis suppression (By similarity). May act as a spontaneously active, calcium-permeable plasma membrane channel. Interacts with TRPM3; the interaction results in the formation of a heteromultimeric cation channel complex.

Also known as TRPM1_HUMAN, TRPM1, LTRPC1, MLSN, MLSN1. Forms nonselective divalent cation-conducting channels which mediate the influx of Na(2+), Ca(2+), Mg(2+), Mn(2+), Ba(2+), and Ni(2+) in ...

EXTERNAL LINKS

TRPM1

Transient receptor potential cation channel subfamily M member 1

TRPM1

Molecular Synopsis