FEATURES

FAMILY

Cation-independent O-methyltransferase family

DESCRIPTION

Also known as NCSB1_STRCZ, ncsB1. S-adenosyl-L-methionine-dependent O-methyltransferase that catalyzes regiospecific methylation at the 7-hydroxy group of 2, 7-dihydroxy-5-methyl-1-naphthoate in the biosynthesis of the naphthoate moiety of the neocarzinostatin chromophore. Also recognizes other dihydroxynaphthoate as substrates and catalyzes their regiospecific O-methylation. The carboxylate and its ortho-hydroxy groups of the substrate appear to be crucial for NcsB1 substrate recognition and binding, and O-methylation takes place only at the free hydroxy group of these dihydroxynaphthoic acids.

EXTERNAL LINKS

uniprot
enzyme classification

ncsB1

2, 7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase

ncsB1

Molecular Synopsis