FEATURES

FAMILY

DESCRIPTION

Also known as 5EAS1_NICAT, EAS. Catalyzes the cyclization of trans, trans-farnesyl diphosphate (FPP) to the bicyclic intermediate 5-epi-aristolochene, initial step in the conversion of FPP to the sesquiterpenoid antifungal phytoalexin capsidiol. Produces germacrene A as an enzyme-bound intermediate that is not released by the enzyme, but is further cyclized to produce the bicyclic 5-epi-aristolochene. Monomer.

EXTERNAL LINKS

uniprot
enzyme classification

EAS

5-epi-aristolochene synthase 1

EAS

Molecular Synopsis