FEATURES

FAMILY

DESCRIPTION

Also known as EPG6_CAEEL, epg-6. Component of the epg-6/atg-2 complex, which is involved in the generation of autophagosomes from omegasomes and in the distribution of atg-9 and atg-13 during the autophagy-mediated degradation of protein aggregates (PubMed:21802374). Binds to phosphatidylinositols on preautophagosomes, which are early autophagic structures, to promote autophagosome formation (PubMed:21802374). In particular, binds with high affinity to phosphatidylinositols including phosphatidylinositol 3-phosphate (PtdIns(3)P) and phosphatidylinositol 5-phosphate (PtdIns(5)P), but more weakly to phosphatidylinositol 4-phosphate (PtdIns(4)P) and phosphatidylinositol 3, 5-bisphosphate (PtdIns(3, 5)P2) (PubMed:21802374). Involved in autophagy-mediated degradation of ribosomal RNA and ribosomal proteins in lysosomes, which is essential for maintaining nucleotide homeostasis (PubMed:30102152). Interacts with atg-2; the interaction is direct.

epg-6

Structural Ligandability

Domains Chains

Distribution