FEATURES

FAMILY

monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

DESCRIPTION

Also known as SL9B2_HUMAN, SLC9B2, NHA2, NHEDC2. Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed:22948142, PubMed:18508966). Contributes to the regulation of intracellular pH, sodium homeostasis, and cell volume. Plays an important role for insulin secretion and clathrin-mediated endocytosis in beta-cells (By similarity). Involved in sperm motility and fertility (By similarity). It is controversial whether SLC9B2 plays a role in osteoclast differentiation or not (By similarity). Homodimer (PubMed:28071645).

Also known as SL9B2_HUMAN, SLC9B2, NHA2, NHEDC2. Na(+)/H(+) antiporter that extrudes Na(+) or Li(+) in exchange for external protons across the membrane (PubMed:18000046, PubMed:28154142, PubMed: ...

EXTERNAL LINKS

SLC9B2

Sodium/hydrogen exchanger 9B2

Mutations

Mutation(s) distribution

Mutations table

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