FEATURES

FAMILY

DESCRIPTION

Also known as VASH2_HUMAN, VASH2, VASHL. Tyrosine carboxypeptidase that removes the C-terminal tyrosine residue of alpha-tubulin, thereby regulating microtubule dynamics and function (PubMed:29146869). Critical for spindle function and accurate chromosome segregation during mitosis since microtuble detyronisation regulates mitotic spindle length and postioning (PubMed:31171830). Acts as an activator of angiogenesis: expressed in infiltrating mononuclear cells in the sprouting front to promote angiogenesis (PubMed:19204325). Plays a role in axon formation (PubMed:31235911). Interacts with SVBP; interaction enhances VASH2 tyrosine carboxypeptidase activity.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

VASH2

Tubulinyl-Tyr carboxypeptidase 2

VASH2

Molecular Synopsis