FEATURES

FAMILY

DESCRIPTION

Also known as BPHL_HUMAN, BPHL, MCNAA. Serine hydrolase that catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. Activates valacyclovir to acyclovir. May play a role in detoxification processes. It is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Monomer. May also form homodimers.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

BPHL

Valacyclovir hydrolase

BPHL

Molecular Synopsis