FEATURES

FAMILY

DESCRIPTION

Also known as PAR10_MOUSE, Parp10. ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate and aspartate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation. Catalyzes mono-ADP-ribosylation of GSK3B, leading to negatively regulate GSK3B kinase activity. Involved in translesion DNA synthesis in response to DNA damage via its interaction with PCNA. Interacts with MYC. Interacts with PARP14. Interacts (via-PIP box and ubiquitin-interacting motifs) with PCNA.

EXTERNAL LINKS

uniprot
enzyme classification

Parp10

Protein mono-ADP-ribosyltransferase PARP10

Parp10

Structural Ligandability

Domains Chains

Distribution