FEATURES

FAMILY

DESCRIPTION

Also known as MNTA_SHEON, mntA. Antitoxin component of a type VII toxin-antitoxin (TA) system. Upon overexpression in situ or in E.coli neutralizes the effect of cognate toxin HepT (PubMed:26112399, PubMed:29555683, PubMed:33045733). Neutralization is mostly due to tri-AMPylation of toxin by this enzyme. Successively tri-AMPylates HepT on 'Tyr-104' (PubMed:33045733). Binds its own promoter, probably repressing its expression. The TA system confers plasmid stability in E.coli (PubMed:26112399). Forms a complex with cognate toxin HepT, may form a homodimer by itself (PubMed:26112399). Forms a heterooctamer with cognate toxin HEPN with stoichiometry HepT(6):MntA(2). The 2 MNT subunits do not contact each other in the heterooctamer, each contacts 3 HEPN subunits, blocking access to the toxin active site (PubMed:29555683).

EXTERNAL LINKS

mntA

Protein adenylyltransferase MntA

mntA

Molecular Synopsis