FEATURES

FAMILY

DESCRIPTION

Also known as SUVH4_ARATH, SUVH4, KYP, SDG33, SET33. Histone methyltransferase. Methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. The silencing mechanism via DNA CpNpG methylation requires the targeting of chromomethylase CMT3 to methylated histones, probably through an interaction with an HP1-like adapter. By its function, KYP is directly required for the maintenance of the DNA CpNpG and asymmetric methylation. Involved in the silencing of transposable elements. Interacts with H3 histone.

EXTERNAL LINKS

uniprot
enzyme classification

SUVH4

Histone-lysine N-methyltransferase, H3 lysine-9 specific SUVH4

SUVH4

Molecular Synopsis