FEATURES

FAMILY

DESCRIPTION

Also known as FKB35_PLAF7, FKBP35. Has peptidylprolyl isomerase (PPIase) and co-chaperone activities (PubMed:15664653, PubMed:15850699). Assists protein folding by catalyzing the peptidyl conversion of cis and trans rotamers of the prolyl amide bond of protein substrates (PubMed:15664653, PubMed:15850699, PubMed:23974147). Inhibits calcineurin phosphatase activity in vitro (PubMed:15850699, PubMed:17289400, PubMed:23974147). Plays an essential role in merozoite egress from host erythrocytes (PubMed:15664653, PubMed:23974147). Homodimer (PubMed:17289400). Interacts (via TPR repeats) with HSP90 (probably via MEEVD motif) (PubMed:15850699, PubMed:19691130).

EXTERNAL LINKS

FKBP35

Mutations

Mutation(s) distribution

Mutations table