FEATURES

DESCRIPTION

Also known as CYRPA_PLAF7, CyRPA, pfd1130w. Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:22593616, PubMed:25583518, PubMed:27374406, PubMed:28195530, PubMed:28195038). Required for the assembly of the PfRH5 adhesion complex (or invasion complex) composed of CyRPA, RH5 and RIPR at the interface between the merozoite and the host erythrocyte membranes (PubMed:25583518, PubMed:28186186, PubMed:28195530, PubMed:28195038, PubMed:30542156). This facilitates the binding of RH5 to host receptor BSG/basigin, which leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes and allows Ca(2+) release into the erythrocyte (PubMed:27374406, PubMed:28186186, PubMed:30542156). Component of the PfRH5 adhesion complex composed of 1 copy of CyRPA, RH5 and RIPR; the complex is formed during merozoite invasion of host erythrocytes specifically at the interface between the parasite and host membranes (PubMed:25583518, PubMed:27374406, PubMed:30542156). Following the establishment of the junction between the merozoite and the erythrocyte, CyRPA dissociates from the complex (PubMed:30542156). Within the complex, interacts with RH5 and RIPR (PubMed:28195530, PubMed:30542156). CyRPA recruits RIPR to RH5-P113-BSG complex; the formation of the PfRH5 adhesion complex increases the affinity of RH5 for BSG and probably leads to the release of RH5 from P113 while maintaining the interaction of the PfRH5 adhesion complex with BSG (PubMed:28186186, PubMed:30542156).

Also known as CYRPA_PLAF7, CyRPA, pfd1130w. Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:22593616, PubMed:25583518, PubMed:27374406, PubMed:28195530, PubMed: ...

EXTERNAL LINKS

CyRPA

Cysteine-rich protective antigen

CyRPA

Molecular Synopsis