FEATURES

FAMILY

DESCRIPTION

Also known as DDX60_HUMAN, DDX60. Positively regulates DDX58/RIG-I- and IFIH1/MDA5-dependent type I interferon and interferon inducible gene expression in response to viral infection. Binds ssRNA, dsRNA and dsDNA and can promote the binding of DDX58/RIG-I to dsRNA. Exhibits antiviral activity against hepatitis C virus and vesicular stomatitis virus (VSV). Interacts with EXOSC1, EXOSC4, DDX58/RIG-I, IFIH1/MDA5 and DHX58/LGP2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DDX60

Probable ATP-dependent RNA helicase DDX60

DDX60

Molecular Synopsis