FEATURES

FAMILY

DESCRIPTION

Also known as MAML2_HUMAN, MAML2, KIAA1819. Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. Interacts through its N-terminal region with the ankyrin repeat region of the Notch proteins NOTCH1, NOTCH2, NOTCH3 and NOTCH4. Forms a DNA-binding complex with Notch proteins and RBPSUH/RBP-J kappa.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

MAML2

Mastermind-like protein 2

MAML2

Molecular Synopsis