FEATURES

FAMILY

DESCRIPTION

Also known as HEXA_ASPOZ, nagA, hexA. Selectively hydrolyzes GlcNAcbeta(1->4)GlcNAc (N, N'-diacetylchitobiose) and Gal-NAcbeta(1->4)GlcNAc, but not their C-2 epimers GlcNAcbeta(1->4)ManNAc or Gal-NAcbeta(1->4)ManNAc. However, hydrolyzes both GlcNAcbeta(1->6)GlcNAc and GlcNAcbeta(1->6)ManNAc (Ref.7). Part of the binary chitinolytic system. Involved in hydrolyzation of chitobiose and higher chito-oligomers (produced from cell wall chitin by endochitinases), thus contributing to the formation of germ tubes, fruit-bodies and septa during hyphenation (Probable). Hydrolyzes synthetic substrate p-nitrophenyl-beta-N-acetyl-D-glucosaminide (pNP-GlcNAc) (PubMed:17302431, PubMed:12723619, Ref.7). Hydrolyzes synthetic substrate p-nitrophenyl-beta-N-acetyl-D-galactosaminide (pNP-GalNAc) (PubMed:12723619). Hydrolyzes chromogenic substrate 4-nitrophenyl-2-acetamido-2-deoxyglucopyranoside (PubMed:21505251, PubMed:17509134, PubMed:29239122). Homodimer (PubMed:15494009, PubMed:17302431, PubMed:21505251, PubMed:17509134, PubMed:29239122). Oligosaccharide moieties may also take part in the dimerization. Dimerization is a pH-dependent reversible process (PubMed:17509134). The individual catalytic cores dimerize and the catalytic core of one subunit in the active dimer interacts with the propeptide of the second subunit (PubMed:29239122).

EXTERNAL LINKS

nagA

Beta-hexosaminidase

nagA

Molecular Synopsis