FEATURES

DESCRIPTION

Also known as COL12_MOUSE, Colec12, Clp1, Srcl. Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells (By similarity). Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells (By similarity). The extracellular domain forms a stable trimer (By similarity). The extracellular domain interacts with fibrillar amyloid-beta peptide.

EXTERNAL LINKS

Colec12

Collectin-12

Colec12

Molecular Synopsis