FEATURES

DESCRIPTION

Also known as PLCE1_MOUSE, Plce1, Kiaa1516, Plce. The production of the second messenger molecules diacylglycerol (DAG) and inositol 1, 4, 5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation. In podocytes, is involved in the regulation of lamellipodia formation. Acts downtream of AVIL to allow ARP2/3 complex assembly (By similarity). Interacts with RHOA (By similarity). Interacts with IQGAP1, HRAS, RAP1A, RAP2A, RAP2B and RRAS (By similarity). Interacts with IQGAP1 (PubMed:17086182). Interacts with AVIL (By similarity).

EXTERNAL LINKS

Plce1

1-phosphatidylinositol 4, 5-bisphosphate phosphodiesterase epsilon-1

Plce1

Molecular Synopsis