FEATURES

FAMILY

DESCRIPTION

Also known as PADH_AROEV, padH. Involved in the anaerobic metabolism of phenylalanine and phenylacetate. Catalyzes the oxidative decarboxylation of phenylglyoxylate to benzoyl-CoA and CO(2). It can also react slowly with 2-oxo-3-methylbutanoate and use different electron acceptors such as benzyl viologen, methyl viologen, FAD or FMN, but NAD seems to be the physiological electron acceptor. Also catalyzes an isotope exchange between CO(2) and the carboxyl group which proves partial or complete reversibility of the oxidative decarboxylation reaction. Dimer of heteropentamers composed of an alpha (PadG), a beta (PadI), a gamma (PadE), a delta (PadF) and an epsilon (PadH) subunit.

EXTERNAL LINKS

padH

NADH-dependent phenylglyoxylate dehydrogenase subunit epsilon

padH

Molecular Synopsis