FEATURES

DESCRIPTION

Also known as LRC25_HUMAN, LRRC25, MAPA. Plays a role in the inhibition of RLR-mediated type I interferon signaling pathway by targeting DDX58/RIG-I for autophagic degradation. Interacts specifically with ISG15-associated DDX58 to promote interaction between DDX58 and the autophagic cargo receptor p62/SQSTM1 to mediate DDX58 degradation via selective autophagy (PubMed:29288164). Plays also a role in the inhibition of NF-kappa-B signaling pathway and inflammatory response by promoting the degradation of p65/RELA. Interacts with DDX58 (PubMed:29288164). Interacts with SQSTM1 (PubMed:29288164). Interacts with p65/RELA; this interaction promotes the degradation of RELA through autophagy (PubMed:29044191).

EXTERNAL LINKS

LRRC25

Leucine-rich repeat-containing protein 25

LRRC25

Molecular Synopsis