FEATURES

FAMILY

DESCRIPTION

Also known as JAGN1_HUMAN, JAGN1. Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport: required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils. Interacts with COPA, COPB2 and COPG2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

JAGN1

Protein jagunal homolog 1

JAGN1

Molecular Synopsis