FEATURES

FAMILY

DESCRIPTION

Also known as PAR16_HUMAN, PARP16, ARTD15, C15orf30. Intracellular mono-ADP-ribosyltransferase that may play a role in different processes through the mono-ADP-ribosylation of proteins involved in those processes (PubMed:23103912, PubMed:22701565, PubMed:25043379). May play a role in the unfolded protein response (UPR), by ADP-ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (PubMed:23103912). May also mediate mono-ADP-ribosylation of karyopherin KPNB1 a nuclear import factor (PubMed:22701565). May not modify proteins on arginine or cysteine residues compared to other mono-ADP-ribosyltransferases (PubMed:22701565). Interacts with KPNB1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PARP16

Protein mono-ADP-ribosyltransferase PARP16

PARP16

Molecular Synopsis