FEATURES

DESCRIPTION

Also known as ANR31_HUMAN, ANKRD31. Required for DNA double-strand breaks (DSBs) formation during meiotic recombination. Regulates the spatial and temporal patterns of pre-DSB recombinosome assembly and recombination activity by acting as a scaffold that anchors REC114 and other factors to specific genomic locations, thereby regulating DSB formation. Plays a key role in recombination in the pseudoautosomal regions of sex chromosomes. Interacts with REC114; the interaction is direct. Interacts with IHO1.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ANKRD31

Ankyrin repeat domain-containing protein 31

ANKRD31

Molecular Synopsis