FEATURES

DESCRIPTION

Also known as PHC3_HUMAN, PHC3, EDR3, PH3. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Component of a PRC1-like complex.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PHC3

Polyhomeotic-like protein 3

PHC3

Molecular Synopsis