FEATURES

FAMILY

DESCRIPTION

Also known as CSK23_HUMAN, CSNK2A3, CSNK2A1P. Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-regulating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression. Heterotetramer composed of two catalytic subunits (alpha chain and/or alpha' chain) and two regulatory subunits (beta chains) (By similarity). Interacts with PML.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

CSNK2A3

Casein kinase II subunit alpha 3

CSNK2A3

Molecular Synopsis