FEATURES

FAMILY

DESCRIPTION

Also known as ODP2_CORGL, aceF, sucB. Is essential for both 2-oxoglutarate dehydrogenase (ODH) and pyruvate dehydrogenase (PDH) activities, but AceF has exclusively transacetylase (and no transsuccinylase) activity. The lipoyl residues required for ODH activity are likely provided by AceF. Forms a 24-polypeptide structural core with octahedral symmetry (By similarity). Part of an unusual ODH/PDH supercomplex, consisting of AceE (E1), AceF (E2), and Lpd (E3) together with OdhA (E1+E2).

EXTERNAL LINKS

uniprot
enzyme classification

aceF

Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex

aceF

Molecular Synopsis