FEATURES

FAMILY

mandelate racemase/muconate lactonizing enzyme family

DESCRIPTION

Also known as FUCD_XANCP, XCC4069. Plays a role in the catabolism of L-fucose. Catalyzes the dehydration of L-fuconate to 2-keto-3-deoxy-L-fuconate by the abstraction of the 2-proton to generate an enediolate intermediate that is stabilized by the magnesium ion. L-fuconate is the preferred substrate with 15-fold lower activity observed for L-galactonate and 8-fold lower activity with D-arabinonate. No activity detected with D-fuconate. Can also catalyze the epimerization of L-talonate and D-ribonate, but at slow rates. Homodimer.

EXTERNAL LINKS

uniprot
enzyme classification

XCC4069

L-fuconate dehydratase

XCC4069

Molecular Synopsis