FEATURES

DESCRIPTION

Also known as CIPC_MOUSE, Cipc, Kiaa1737. Transcriptional repressor which may act as a negative-feedback regulator of CLOCK-ARNTL/BMAL1 transcriptional activity in the circadian-clock mechanism. May stimulate ARNTL/BMAL1-dependent phosphorylation of CLOCK (PubMed:17310242, PubMed:19414601). However, the physiogical relevance of these observations is unsure, since experiments in knockout mice showed that CIPC is not critially required for basic circadian clock (PubMed:25862660). Interacts with CLOCK. Forms a ternary complex with the CLOCK-ARNTL/BMAL1 heterodimer. Interacts with CAD AND HSPA5 (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

Cipc

Mutations

Mutation(s) distribution

Mutations table