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FEATURES

FAMILY

DESCRIPTION

Also known as DOT1L_HUMAN, DOT1L, KIAA1814, KMT4. Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). Binds to DNA (PubMed:12628190). Interacts with MLLT10.

Also known as DOT1L_HUMAN, DOT1L, KIAA1814, KMT4. Histone methyltransferase. Methylates 'Lys-79' of histone H3. Nucleosomes are preferred as substrate compared to free histones (PubMed:12123582). B ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DOT1L

Histone-lysine N-methyltransferase, H3 lysine-79 specific

Mutations

Mutation(s) distribution

Mutations table

Search Mutation

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