FEATURES

FAMILY

DESCRIPTION

Also known as SHRM3_HUMAN, SHROOM3, KIAA1481, SHRML. Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity). Interacts with F-actin (By similarity). Interacts with ROCK1 (PubMed:22493320).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SHROOM3

Mutations

Mutation(s) distribution

Mutations table