FEATURES

FAMILY

DESCRIPTION

Also known as HASP_HUMAN, HASPIN, GSG2. Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

HASPIN

Serine/threonine-protein kinase haspin

HASPIN

Molecular Synopsis