FEATURES

FAMILY

DESCRIPTION

Also known as TIRR_MOUSE, Nudt16l1, Sdos, Tirr. Key regulator of TP53BP1 required to stabilize TP53BP1 and regulate its recruitment to chromatin. In absence of DNA damage, interacts with the tandem Tudor-like domain of TP53BP1, masking the region that binds histone H4 dimethylated at 'Lys-20' (H4K20me2), thereby preventing TP53BP1 recruitment to chromatin and maintaining TP53BP1 localization to the nucleus. Following DNA damage, ATM-induced phosphorylation of TP53BP1 and subsequent recruitment of RIF1 leads to dissociate NUDT16L1/TIRR from TP53BP1, unmasking the tandem Tudor-like domain and allowing recruitment of TP53BP1 to DNA double strand breaks (DSBs). Binds U8 snoRNA. Homodimer (PubMed:26100207). Interacts with TP53BP1 (via the Tudor-like domain); interaction is abolished following DNA damage and TP53BP1 phosphorylation by ATM (By similarity). Interacts (via the cytoplasmic part) with SDC4 (PubMed:11805099). Interacts with TGFB1I1 and PXN (PubMed:11805099).

EXTERNAL LINKS

Nudt16l1

Tudor-interacting repair regulator protein

Nudt16l1

Molecular Synopsis