FEATURES

FAMILY

glycerophosphoryl diester phosphodiesterase family

DESCRIPTION

Also known as GDPD5_HUMAN, GDPD5, GDE2. Glycerophosphodiester phosphodiesterase that promotes neurite formation and drives spinal motor neuron differentiation (By similarity). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (By similarity). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). Interacts with PRDX1; forms a mixed-disulfide with PRDX1, leading to disrupt intramolecular disulfide bond between Cys-25 and Cys-571.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

GDPD5

Glycerophosphodiester phosphodiesterase domain-containing protein 5

GDPD5

Molecular Synopsis