FEATURES

DESCRIPTION

Also known as CLC4C_HUMAN, CLEC4C, BDCA2, CLECSF11, CLECSF7, DLEC, HECL. Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed:21880719, PubMed:25995448). Specifically recognizes non-sialylated galactose-terminated biantennary glycans containing the trisaccharide epitope Gal(beta1-3/4)GlcNAc(beta1-2)Man (PubMed:21880719, PubMed:25995448). Binds to serum IgG (PubMed:25995448). Efficiently targets ligand into antigen-processing and peptide-loading compartments for presentation to T-cells (PubMed:11748283). May mediate potent inhibition of induction of IFN-alpha/beta expression in plasmacytoid dendritic cells (PubMed:11748283, PubMed:21880719). May act as a signaling receptor that activates protein-tyrosine kinases and mobilizes intracellular calcium (PubMed:11748283). Homodimer.

Also known as CLC4C_HUMAN, CLEC4C, BDCA2, CLECSF11, CLECSF7, DLEC, HECL. Lectin-type cell surface receptor which may play a role in antigen capturing by dendritic cells (PubMed:11748283, PubMed ...

EXTERNAL LINKS

CLEC4C

Mutations

Mutation(s) distribution

Mutations table