FEATURES

FAMILY

zinc-containing alcohol dehydrogenase family

DESCRIPTION

Also known as ETR1_CANTR, ETR1. Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment. Homodimer and heterodimer with ETR2.

EXTERNAL LINKS

uniprot
enzyme classification

ETR1

Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial

ETR1

Molecular Synopsis