FEATURES

FAMILY

DESCRIPTION

Also known as DACA_LISMO, dacA, cdaA. Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP) (PubMed:25605729). c-di-AMP is a signaling compound secreted into the host's cytosol where it triggers the cytosolic surveillance pathway (CSP), a host pathway of innate immunity characterized by expression of beta interferon (IFN-beta) and coregulated genes (PubMed:20508090). Expression of truncated proteins (missing first 80 or 100 residues) in E.coli leads to c-di-AMP synthesis (PubMed:25605729). Homodimer, required for active site formation (Probable).

EXTERNAL LINKS

uniprot
enzyme classification

dacA

Mutations

Mutation(s) distribution

Mutations table