FEATURES

FAMILY

DESCRIPTION

Also known as OSBL1_MOUSE, Osbpl1a, Orp1, Orp1a, Orp1l. Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol. Interacts with VAPA (By similarity). Interacts with the GTP-bound form of RAB7A (By similarity). Interacts with OAS1B (PubMed:22623793). Interacts (via FFAT motif) with MOSPD2 (via MSP domain) (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification

Osbpl1a

Oxysterol-binding protein-related protein 1

Osbpl1a

Molecular Synopsis