FEATURES

DESCRIPTION

Also known as SHC3_HUMAN, SHC3, NSHC, SHCC. Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons. Interacts with the Trk receptors in a phosphotyrosine-dependent manner. Once activated, binds to GRB2. Interacts with activated EGF receptors.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SHC3

SHC-transforming protein 3

SHC3

Molecular Synopsis