FEATURES

FAMILY

DESCRIPTION

Also known as KAT6A_HUMAN, KAT6A, MOZ, MYST3, RUNXBP2, ZNF220. Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity. May act as a transcriptional coactivator for RUNX1 and RUNX2. Acetylates p53/TP53 at 'Lys-120' and 'Lys-382' and controls its transcriptional activity via association with PML. Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3. Interacts with RUNX1; phosphorylation of RUNX1 enhances the interaction. Interacts with RUNX2. Interacts with p53/TP53. Interacts with PML (isoform PML-4) and this interaction positively regulates its acetylation activity towards p53/TP53.

Also known as KAT6A_HUMAN, KAT6A, MOZ, MYST3, RUNXBP2, ZNF220. Histone acetyltransferase that acetylates lysine residues in histone H3 and histone H4 (in vitro). Component of the MOZ/MORF complex ...

EXTERNAL LINKS

KAT6A

Mutations

Mutation(s) distribution

Mutations table