FEATURES

DESCRIPTION

Also known as ACD_HUMAN, ACD, PIP1, PTOP, TINT1, TPP1. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. Component of the shelterin complex (telosome) composed of TERF1, TERF2, TINF2, TERF2IP ACD and POT1. Forms heterodimers with POT1. Identified in a complex with POT1 and single-stranded telomeric DNA. Interacts with STN1 and TINF2.

Also known as ACD_HUMAN, ACD, PIP1, PTOP, TINT1, TPP1. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates wit ...

EXTERNAL LINKS

ACD

Adrenocortical dysplasia protein homolog

ACD

Molecular Synopsis