FEATURES

FAMILY

DESCRIPTION

Also known as OTUB2_HUMAN, OTUB2, C14orf137, OTB2, OTU2. Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-, 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

OTUB2

Ubiquitin thioesterase OTUB2

Mutations

Mutation(s) distribution

Mutations table

Search Mutation