FEATURES

DESCRIPTION

Also known as NEUL4_HUMAN, NEURL4, KIAA1787. Promotes CCP110 ubiquitination and proteasome-dependent degradation. By counteracting accumulation of CP110, maintains normal centriolar homeostasis and preventing formation of ectopic microtubular organizing centers. Interacts with CCP110; this interaction propmotes CCP110 ubiquitination and degradation via the proteasome pathway. Via its interaction with CCP110, may indirectly interact with CEP97. Interacts with the E3 ubiquitin-protein ligase HERC2 and UBE3A. May interact with MAPK6 and hence mediate MAPK6 interaction with UBE3A. Interaction with UBE3A may be indirect and mediated by HERC2.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NEURL4

Neuralized-like protein 4

NEURL4

Molecular Synopsis