FEATURES

FAMILY

DESCRIPTION

Also known as TOPK_HUMAN, PBK, TOPK. Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage. Interacts with DLG1 and TP53.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PBK

Lymphokine-activated killer T-cell-originated protein kinase

PBK

Molecular Synopsis