FEATURES

FAMILY

DESCRIPTION

Also known as SAMD8_HUMAN, SAMD8. Sphingomyelin synthases synthesize sphingolipids through transfer of a phosphatidyl head group on to the primary hydroxyl of ceramide. SAMD8 is an endoplasmic reticulum (ER) transferase that has no sphingomyelin synthase activity but can convert phosphatidylethanolamine (PE) and ceramide to ceramide phosphoethanolamine (CPE) albeit with low product yield. Appears to operate as a ceramide sensor to control ceramide homeostasis in the endoplasmic reticulum rather than a converter of ceramides. Seems to be critical for the integrity of the early secretory pathway.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

SAMD8

Sphingomyelin synthase-related protein 1

SAMD8

Molecular Synopsis