FEATURES

FAMILY

DESCRIPTION

Also known as NALP4_HUMAN, NLRP4, NALP4, PAN2, PYPAF4, RNH2. May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways. Interacts with CHUK/IKKA, inhibiting its kinase activity.

Also known as NALP4_HUMAN, NLRP4, NALP4, PAN2, PYPAF4, RNH2. May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membran ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NLRP4

NACHT, LRR and PYD domains-containing protein 4

NLRP4

Molecular Synopsis