FEATURES

DESCRIPTION

Also known as NOX5_HUMAN, NOX5. Calcium-dependent NADPH oxidase that generates superoxide. Also functions as a calcium-dependent proton channel and may regulate redox-dependent processes in lymphocytes and spermatozoa. May play a role in cell growth and apoptosis. Isoform v2 and isoform v5 are involved in endothelial generation of reactive oxygen species (ROS), proliferation and angiogenesis and contribute to endothelial response to thrombin.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

NOX5

NADPH oxidase 5

NOX5

Molecular Synopsis