FEATURES

DESCRIPTION

Also known as RHG07_HUMAN, DLC1, ARHGAP7, KIAA1723, STARD12. Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.

Also known as RHG07_HUMAN, DLC1, ARHGAP7, KIAA1723, STARD12. Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. T ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

DLC1

Mutations

Mutation(s) distribution

Mutations table