FEATURES

FAMILY

DESCRIPTION

Also known as PANX1_HUMAN, PANX1, MRS1. Structural component of the gap junctions and the hemichannels involved in the ATP release and nucleotide permeation (PubMed:16908669, PubMed:20829356, PubMed:30918116). May play a role as a Ca(2+)-leak channel to regulate ER Ca(2+) homeostasis (PubMed:16908669). Plays a critical role in oogenesis (PubMed:30918116). Homohexamer. Forms homomeric or PANX1/PANX2-heteromeric intercellular channels on coexpression in paired Xenopus oocytes (By similarity).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PANX1

Pannexin-1

PANX1

Molecular Synopsis