FEATURES

DESCRIPTION

Also known as HTF4_HUMAN, TCF12, BHLHB20, HEB, HTF4. Transcriptional regulator. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Efficient DNA binding requires dimerization with another bHLH protein. Forms homo- or heterooligomers with myogenin, E12 and ITF2 proteins. Interacts with PTF1A. Interacts with NEUROD2 (By similarity). Interacts with RUNX1T1. Interacts with AML1-MTG8/ETO (via nervy homology region 2 in oligomerized form) (PubMed:23812588). Interacts with BHLHA9 (PubMed:25466284).

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TCF12

Mutations

Mutation(s) distribution

Mutations table