FEATURES

FAMILY

DESCRIPTION

Also known as PHX2B_HUMAN, PHOX2B, PMX2B. Involved in the development of several major noradrenergic neuron populations, including the locus coeruleus. Transcription factor which could determine a neurotransmitter phenotype in vertebrates. Enhances second-messenger-mediated activation of the dopamine beta-hydrolase and c-fos promoters, and of several enhancers including cAMP-response element and serum-response element. Interacts with TRIM11.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

PHOX2B

Paired mesoderm homeobox protein 2B

PHOX2B

Molecular Synopsis