FEATURES

DESCRIPTION

Also known as ADAM2_HUMAN, ADAM2, FTNB. Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

ADAM2

Disintegrin and metalloproteinase domain-containing protein 2

ADAM2

Molecular Synopsis